First draft prepared

Explanation.................................................................................................... 333 Evaluation for acceptable daily intake .......................................................... 333 Biochemical aspects ................................................................................ 333 Absorption, distribution and excretion .............................................. 333 Biotransformation .............................................................................. 337 Toxicological studies ............................................................................... 337 Acute toxicity ..................................................................................... 337 Ocular and dermal irritation......................................................... 339 Dermal sensitization ..................................................................... 339 Short-term studies of toxicity ............................................................ 339 Oral administration....................................................................... 339 Exposure by inhalation................................................................. 354 Long-term studies of toxicity and carcinogenicity............................ 355 Genotoxicity ....................................................................................... 360 Reproductive toxicity ......................................................................... 360 Multigeneration study................................................................... 360 Developmental toxicity................................................................. 364 Special studies.................................................................................... 370 Neurotoxicity ................................................................................ 370 Acute neurotoxicity ...................................................................... 372 Neurotoxicity after repeated doses............................................... 374 Studies on metabolites.................................................................. 376 Observations in humans .......................................................................... 379 Comments...................................................................................................... 379 Toxicological evaluation................................................................................ 382 References ..................................................................................................... 384